I Contain Multitudes: The Microbes Within Us and a Grander View of Life

“I Contain Multitudes” by Ed Yong explains in 355 pages the amazing benefit that microbes have on earth and in us. This 2016 non-fiction novel informs his readers about the world of microbes and the symbiotic relations they have with their host through a variety of examples as the author dives into the world of microbes. Ed Yong is an award winning science writer that breaks down this new small world in easy to digest layman examples to educate readers the importance of these small organisms with their host. He has traveled to many institutions and spoke the experts of various fields in the world of microbiology to understand the tremendous impact that microbes have. He mainly goes into the world of animals and their relationship with microbes, but he wonderfully connects these examples to help us understand the future of probiotics and disease in humans. As Yong goes into his examples, it is clear that the microbial world is in a delicate balance with our reality. Although he does focuses on animal, mainly humans and their relationship with microbes, he does points out that Jack Gilbert and Josh Neufeld stated if plants were don’t have any microbes, they surely will fail and can lead to societal collapse because there food chain would fail. Plants depends on microbes to fix nitrogen or give it key nutrients to help the plants flourish. This example he uses early on in the book really set the tone for the rest of the examples and how far a single microbe influence can have a snowball effect on us. Ed starts the reader’s journey with Baba, a pangolin at the San Diego Zoo with Baba’s keeper swabbing the Baba’s body to understand his microbiome. Ed lays out the foundation to the rest of the book by explaining basic key terms and concepts of the diversity of microbes on the body. As the book progress, Ed goes into the importance of microbes to humans. He states that if animals were sterile, free of any microbes, they would die. For example, if sap-sucking bugs lack their bacteria in their gut, they would parish because they wouldn’t be able to get all the nutrients they need without those important bacteria. Like Baba, humans have their own unique microbiome throughout their body, like the how the skin microflora differs from the gut microflora. This diversity on the human body is so interesting, that even the microflora of the right hand would be different than the microflora of the left hand. This diversity is also unique from person to person. The journey of a human obtaining their own unique microbiome starts at birth. In the womb, the fetus is completely sterile, but during birth, the baby obtains its first microbes can be traced back to their mom. He does goes into how the differences of birthing method, vaginal and cesarean section affects a child’s first microbes. These microbes can affect the child’s immune responses in the future. Even having a pet or an older sibling in the development of a child can may reduce the possibility of allergies of the child as a result of constant exposure at a young age to a variety of microbes from diverse locations. This trains the immune system at an early age to help fight infections later in life. It is emphasized that a mother is the biggest player in shaping the child’s microbiome. Not just from the birthing method, but also the role of breast milk. Yong divulges in the amazing properties of break milk for babies on how it plays a huge role on a babies gut microbiota. Breast milk is one of humans first prebiotic for a baby, since it not only nourishes and protect the immune system of the baby, but provides nutrients to the child’s first set of bacteria, L. infantilis in their gut. Yong even states that the gut microbiome can also affect behavior. He starts his example with lab mice, and if pregnant mother with infection during pregnancy, it can have healthy offspring that can have behavioral abnormalities in adulthood such as repetitive behaviors and social aversion, which is similar to the humans conditions of autism and schizophrenia. When looking at the gut microbiota diversity of a mice with such quirks to a normal mouse, there is a difference in the variety, even when everything is the same, such as environment and nutrition. This behavior in mice is relates to behavior in autistic individuals, although it is stated that mice don’t have autism since autism, according to Emily Willingham, is shaped by society and what seems to be normal. When gut microbes from autistic children were transplanted into the gut of healthy mice, the mice’s behavior did change by repetitive burying of a marble and low frequency of squeaks, which could be related to autistic behaviors of children. Yong mentions that that the gut microbe are partially responsible for such behaviors in autistic children, but it cannot be the sole reason. Fascinatingly, germ free mice that lacked a gut microbiome had behavior differences of their normal microbiota counterpart, these mice were more timid. When introduced to the bacteria commonly found in yoghurt and dairy products, Lactobacillus rhamnosus, specifically the strain JB-1 to their gut, the mice were able to overcome anxiety through the same tests that were made to test psychiatric drugs. Apparently, the strain JB-1 acted like a low dose of anti-anxiety and antidepressants, according to Cyan from the University of Cork. The researched looked into the brains of the mice of JB-1 and showed that brains response to GABA changed with the strain. The suspected that the nerve that that carries signal from the brain to gut aided JB-1 in the influence of the improved behavior in the mice. Yong informs reader of current research that correlated the behavior to the gut microbiota, demonstrated that there is more than meets the eye of the microflora animals. Not only does the book go into detail of the symbiosis humans and their microbes, it proved examples of how microorganisms help with survival of the host, like the illuminating Vibrio fischeri and the Hawaiian bobtail squid. When the Hawaiian bobtail squid hatches from their egg, it is born without V. fischeri. Interestingly enough, the bobtail squid has immature crypts which houses these bacteria. When V. fischeri goes to colonize the squid. Once these bacteria colonize the squid, it start to mature the remaining organs to help it survive in their environment. It take more than just a few of the V. fischeri to help the Hawaiian bobtail squid survive. Once the bacteria reached a certain threshold of one turn on their bioluminescent to hide the bobtail squid’s shadow in the water and also produce antimicrobial properties to it can reduce competition by making it impossible for other microbes to occupy the bobtail. In exchange for helping the bobtail squid V. fischeri gains protection and a constant supply of nutrients. The symbiosis of a microorganism and its host can be an indicator of the health of the host and environment, such as dying coral reefs on Christmas Island. The dying reefs are a prime example of a delicate balance of the symbiosis of microbes, because a reason for these reefs to dye is algae. The rise of algae is a result of the disruption of the food chain, such as the decrease of sharks. Sharks host an abundance of algae, if they are gone, the algae population stays in the water as wells are the production of dissolved organic carbon. This dissolved organic carbon will allow the microbe populations toe exponentially increase; therefore, consuming all the surrounding oxygen, essentially chocking the corals. Usually there are 10 percent of the local microbe species in coral are pathogenic and cause disease because the normal coral microflora keeps the population of microbes in check. Around Christmas Island it is around 50 percent because of the abundance of nutrients from the algae. As coral die, it makes room for more of this algae to grow, which leads to a never ending cycle of dying coral and flourishing microbial community and algae. As Yong enlightens readers of the benefit of microbes in the world, he leads us to microbes place in medical field. Like his previous example of the how microbes can affect behavior, he leads us to thinking about the potential uses of microbes in treating diseases or maximizing the effect of medicine. For example, digoxin has been used to treat patients with hearts that are failing, but it the patients has Eggerthella lenta in their gut microbiome, digoxin will not work because the bacteria converts the drug into an inactive form. This isn’t the only drug and microbe pair that affect treatment. Yong brings up fecal transplant or a more refined and cleaner version to be the future of treatments, not just in behavior but in all sorts of treatments to help reduce symptoms or treat disease. Even brings up that inside the hospital is riddling with a high concentrations pathogenic microbes, but if a window is just opened to allow the outside microbes to come in and occupy space in the hospital. These outside microbes in the environment will push out and decrease the pathogenic microbial population. Readers do not need to come from a science background to read and thoroughly understand this book, because Ed Yong wonderfully explains the purpose of each example and how it correlated back the balance of a delicate symbiosis of the microbe and its host. This book is amazing to for readers of all backgrounds, but I would recommend this book to mothers, physicians and health fanatics since Ed Yong displays the importance of microbes to the positive health of the human body and the environment. A disruption of microbes can cause huge impact on the host or environment, which can allow us to pinpoint the cause of the disruption. Microbes and their effects are great indicator of the health of where it is occupying. Essentially, microbes are not as evil as we have been taught to think. The issue with Ed Yong’s book is the fact he didn’t mention quorum sensing one in the book, because that would help the reader understand how microbes effect their own population or the community they live with. Also, Ed Yong jumped around a lot in examples, I felt like he could have separated examples by relevance. Personally, I would have started his examples with the symbiosis of the bugs then to talk about the corals the impact of environments. Then use antibiotic resistance as a transition from animals to humans, then go into behaviors affected by microbes. He could have concluded with fecal matter transplant and using microbes as treatments and then ended with the research of tracking a building’s, new or old microbiome. It took until the end to understand the purpose of this book, because Yong starts out with going on this adventure to understand the world of microbes without giving a reason. It later chapters, everything comes together on why this subject is important. The future of medicine and treatments could possibly lie in the hands of the microscopic organisms. Even understanding the environmental health can be indicated by the concentration or shift in diversity of microbes. He mentions that probiotics would be uniquely prescribed to patients with a nutrient regime to either enhance to effectiveness of medicine or to be the medicine itself to help with certain symptoms or diseases. Over all, Ed Yong did an amazing job on informing readers on the world of microbes in a way that a variety of backgrounds could understand.

This is a fine book about microbial evolution. I makes the case for the thesis that microbes are ubiquitous, important and understudied. It looks at the relationship between mucrobes and humans, but also delves into the relstionships between microbes and many other animals. Plants and fungi were not so well represented. The book is accessible and well-written. A slight issue was some youthful wow factor. The author sometimes enthused about things that I thought were old hat. My other main criticisms are errors of omission. I usually feel pretty mean-spirited criticing books for what is not in them, but it sometimes needs doing. The book's focus on microbes - but it also discusses a number of topics related to symbiology - since microbes are often animal symbionts. However, these discussions always revolved around microbial examples. For example the obesity epidemic was discussed, while the smoking epidemic was not. The reason, obesity is partly-mediated by microbial symbionts (candida, etc) - while smoking involves a symbiosis between humans and a plant. With obesity, microbes are involved, but so are cultural symbionts - memes. In the case of the obseity epidemic it is hard to have a sensible discussion without considering which aspects are influenced by memes and which involves genes in humans and plants and microbes. Here the author focuses on the influence of microbes and treatments involving fecal transplants. In this and some other cases, the microbial focus starts to look blinkered. I guess I was more interested in the symbiology than the microbes. Overall, the book had a fairly reasonable balance between theory and examples, but I still wanted more theory - and fewer examples. The book was a lot like a microbial natural history program. Natural history programs are often short on theory. To give an example, the book discusses the hypothesis that symbionts make their hosts more sociable - to spread between them better when they engage in social contact. This is in my opinion, a big and important hypothesis. However the book only gives it one short paragraph. I wanted more. Having criticized a but, this is still a great book on microbes. I has got to be rated pretty high on the list of popular science books on the topic. Good job. Ed has some related videos and articles online if you want a trailer. Many of these are also worthwhile. I plan to follow Ed Yong's work in the future.

All of us have a microbiome: a community of microorganisms, including bacteria, yeasts, and archaea, that reside on the surface of or within our bodies. There are billions, and they are everywhere. There are likely more bacteria in your gut than stars in the galaxy. This book is about all of them. Microbes come in many forms: commensal, where an organism benefits from another without causing any harm (e.g. bacteria on the human skin); mutualism, where both organisms benefit (gut bacteria aiding in digestion while producing essential vitamins); parasitic, where one organism (the parasite) benefits at the expense of another (the host); and more. It is in this sense, all considered, in which we contain multitudes. What I enjoyed about the text was the author's authentic scientific curiosity that oozed through the pages. The book follows a clear cadence:: In the beginning stages, we get an overview of the beginnings and background of the field of microbiology. These discussions revolved around seminal figures such as Leeuwenhoek, Martinus Beijerinck, Robert Hooke, Louis Pasteur, Robert Koch, Heinrich Anton de Bary, and more. In the middle we get a tour in the form of numerous examples of how microbes shape nature and us, from human development and health, to coral reefs and squid. And towards the end the discussion revolves around ways we can utilize our knowledge and harness microbes for the greater good (e.g. Wolbachia to block dengue, microbiome-guided medicine, ecological approaches rather than carpet-bombing with antibiotics). Some memorable discussions include: - Hawaiian bobtail squid. It recruits luminous bacteria called Vibrio fischeri that at night matches the moonlight so that it's silhouetted shadow is cancelled and therefore it can more effectively evade predation. This section reviews the seminal work of Margaret McFall-Ngai and colleagues on the Vibrio fischeri–bobtail squid symbiosis, touching on the physics and chemistry that guide colonization. The latter is treated briefly and can be a bit misleading: the text says cilia on the light organ create a “turbulent” current that draws in bacteria, but at this microscopic scale the flow is laminar (Stokes) flow, more like syrup than a whirlwind. Ciliary beating produces directed micro-currents and near-surface vortices that focus particles of bacterial size—V. fischeri among them—while mucus and chemistry do the filtering. Even so, the background, science, and people behind these discoveries are fascinating. - Wolbachia. Discussions involving this bacteria reoccur throughout the book. Besides being the author's favorite microbe, it is a quintessential example of the dual nature of microbes as being both partners or parasites depending on the context. It's an intracellular bacterium that lives in the cells of a huge fraction of arthropods and probably the most common animal symbiont on Earth. It is said to infect at least four in every ten species of arthropods, the animal group that includes insects, spiders, scorpions, and more. The way it can manipulate speciation, reproduction, and anything from nematodes to leaves of apple trees is fascinating. The bigger lesson here is that they flip the old script -- equating germs to enemies -- upside down. It is a classic example of microbes being ecosystem engineers inside animals, as selfish manipulators or indispensable partners depending on how you look at it. Through them, we can learn how to harness microbes responsibly. - Coral Reefs. They are a diverse underwater ecosystem built by coral polyps They are considered a holobiont, which is a community comprised of a host and many other species living around it or benefiting directly from it. This dense microbiome is comprised of bacteria, archaea, viruses and fungi. Coral reefs are essential for the health of many oceanic ecosystems. When heat and pollution enter the fray, many of the symbiotic partnerships inside of the coral reefs unravel. - Newborns. From the moment of conception to breastfeeding, a newborn's life is surrounded by a surfeit amount of microbes. Early life is a critical window where the right balance of microbial exposure must be struck: too many can cause harm; too few can tilt the axis of susceptibility towards asthma and allergies. There are interesting discussions revolving around the early use of antibiotics, HMOs, IgA antibodies, and more. While I do think the book is interesting and would be worthwhile to any prospective reader with a broad scientific interest, I would more pointedly recommend this book to someone who is interested in the subject matter, or anything tangential to it. It's not an academic level text and therefore there wouldn't be any pre-requisites to picking it up and learning. That being said, if you are not interested or do not have at least a little bit of background in layman science you may easily get bored or lost.

Ed Yong is a magnificent storyteller who guides the reader through the invisible yet ever present microbial world. An insightful read.

Ed Yong's first book is a fantastic foray into the unseen world of bacteria: how they colonise us, cohabitate with us, and even control us. Though they go largely unseen, they are critical for almost all life on earth. A confession: I've been a fan of Ed Yong's writing for a while. A few years back, when I was considering science journalism myself, I found his work over at Not Exactly Rocket Science. It was (and is) an informative and inspirational blog that tackles complicated science well and with great humour. So when I saw that he had released a book, I bought it straight away. For full price. If you know me, that's almost a recommendation in itself. But while it might seem like I was always destined to have enjoyed this book, I was still pleasantly surprised with how good a read it was. Yong shares the scientist's love of an elegant experiment, and the journalist's love of a great narrative hook; these two loves pleasingly intersect in enjoyable narratives that are compelling while being lucid and well-researched. This is the sort of science writing that doesn't shy away from complexity, but is written well enough that the average lay person could understand - it tackles the difficult task of addressing multiple audiences in the same volume well. A scientifically-minded reader will be sated by the level of detail without being bored by remedial repetition. Mainly, I enjoyed this book because Yong paints bacteria with a complete palette, describing friends, competitors and sometimes foes. This makes it a compelling read, as most often popular science literature refers to bacteria in a binary sense: 'good' bacteria or 'bad' bacteria, an adversarial fairy tale which undercuts the full spectrum occupied by the thousands of bacterial species that make our body their home. The subtlety and nuance in this book is refreshing, and I wish more writers took the time to do the subject justice. Highly recommended.

This book is fascinating, and paints an amazing picture about how biology, and in particular the study of microbes has changed dramatically in the last 350 years or so. From Van Leeuwenhoek's first glimpse of a microbe, to their languishing in obscurity only to be rediscovered and cast as the villain, to finally being in the spotlight of biology in the modern day - this book takes you through the entire journey. At a glance: This book is a well written novice's entry into the world of microbes. He doesn't skimp on the important complicated bits, but uses well thought-out metaphors that help illustrate the complex events and relationships. For bonus points, he's sought out some amazing scientists to make cameos and reference their real-world research on the topic. This elevates the book to be more than just a fun-to-read explanation of microbes, but an inspirational collection of real people doing really amazing things in an effort to make our world healthier. That, to me, is the coolest aspect of this book. Scott O'Neil eliminating Dengue with Wolbachia Jack Gilbert uncovering all of the microbes leading to collaborations towards healthier buildings and cities CONS This book has extremely long chapters, with very long sentences to fill them. In an effort to tie everything in for the reader the author seems to circle back to the larger theme so often that I found myself getting lost a few times and forgetting where I was. As someone who likes to read chapter by chapter, and who is usually a 'just one more...' type of reader, this required me to dedicate large swatches of time and stop reading earlier than I might have otherwise. GOOD FOR If you're one of those people that carries around a little bottle of hand sanitizer and thinks that all germs are 'bad'.

This is a deeply researched and clearly written exploration of the countless microorganisms that inhabit animals of all kinds, from the tiniest insects to humans and other large mammals. The author gives many examples of how communities of microbes play essential roles in the health and sustainability of host organisms, and how organisms do-evolve with their microbiomes. Certainly, some microbes and microbes combinations cause disease, but others protect and provide essential nutrients. As someone who doesn't think about microbiology that often, I found some parts of the book to full of information that I am unlikely to use or remember. But other parts were downright fascinating, especially those involving genetics, evolution, and emerging ways to manipulate microbiomes to improve human health and save entire groups of species such as frogs from collapse. The book has given me a greater appreciation for the complexity of life, and how careful we must be when we seek to manipulate ecosystems to our advantage. I recommend this book to anyone who appreciates excellent, clear science writing and has, or is willing to cultivate, an appreciation for interactions of diverse microbes, nutrients, hosts and environmental conditions.

Wow! What a science writer— get it!

I contain multitude by Ed Yong is a mind-blowing book. - Every single animal on the planet except for a few genetically engineered animals that are kept gem free. has a whole feast and array of trillion of microbes on its skin but mainly in its gut and throughout its body. This book explores what that means. These microbes live with us, and they help us eat food, digest it and keep our health and well-being good. Yet microbes are so small that ‘a million could dance on the head of a pin’. - Our planet is full of the range of diverse sort of ecosystems and like Earth’s coral reefs, dry arid plains to rainforest and the same can be said of the Microbiome that live on us and within us and every animal on the planet. - The earth is 4.54 billion years old and for most of the time on this planet, the only life form (formed around 3.6 billion years ago) found on earth was microbes. Then, for roughly the first 2.5 billion years of life on Earth, bacteria and archaea followed largely separate evolutionary courses until, on one fateful occasion, a bacterium somehow merged with an archaeon and complex life emerged, and the bacteria become mitochondria (the energy source within all living cells). They became eukaryotes (complex cells with a nucleus). - We are awash with horror stories about how bacteria is everywhere and around us there's only 100 odd pathogens (micro bacteria that causes harm) and most bacteria is beneficial to us. They do a wide range of things through the diversity in our gut. Fermentation helps us to make beer, cheese, kimchee and sauerkraut. We need bacteria and most of it is beneficial rather than causing harm. - There are around 26,000 genes in the DNA that help make us who we are. But in the microbiome, there are hundreds of thousands more genetic makers that makes up the DNA within the microbiome. - BENEFITS: The Microbiome benefits us by “helping us to digest our food, releasing otherwise inaccessible nutrients. They produce vitamins and minerals missing from our diet. They breakdown toxins and hazardous chemicals. They protect us from disease by crowding out more dangerous microbes or killing them directly with microbial chemicals. They produce substances that affect the way we smell. They are such an inevitable presence that we have outsourced surprising aspects of our life to them. They guide the construction of our bodies, releasing molecules and signals at steer the growth of our organs. The educate our immune system, teaching it to tell friend from foe. That that that development of the nervous system and perhaps even influence our behaviour. They contribute to our lives in profound and wide-ranging ways; No corner of our biology is untouched. If we ignore them, we are looking at our lives through a keyhole.” - There are many conditions such as an obesity and autism that we know have a change in the Microbiome, but the question might be what if these are the cause of some of these health conditions and if this is the case what can we do to help support our Microbiome. - HISTORY: If you combine the whole of human planet into a year, the things that make up the Microbiome will have been around and from March to November, they were the only source of life on the planet. Human beings have only been around for 30 seconds – but they continue to exist and live in a symbiotic relationship with us and all living creatures. - OTHER ANIMALS RELATIONSHIPS: Grazing animals like cows and sheep are dependent on their gut microbes to breakdown the tough fibres in the plants that they eat. Great herds of Africa’s grasslands would vanish., and other sap-sucking bugs would perish without their microbiome to supplement the nutrients they're missing from their diets. In oceans, many worms, shellfish and other animals require bacteria for all their energy. Studies in mice that are germ-free show that they live shorter lives and are more susceptible to disease and their anatomy doesn’t develop as it should. - Robert Van Hooke when inventing the first microscope was the first to see these first living creatures naked to human eye in water and his own body but then these bacteria and viruses got linked to disease and germ theory. - The view today of microbes is very different, we think of them as agents of disease and dirt. This is due to many of the most infamous plagues of humanity caused by bacteria or infectious germs. This includes tuberculosis, plague, cholera, leprosy, gonorrhoea and syphilis. All these terrible diseases were the work of microbes and became linked only with things that killed or destroyed us. Yet this reputation is deeply unfair as only a small minority of microbes are responsible for diseases, maybe around 200. The vast majority are benign or beneficial to us and they are in fact the Lords of the planet, they run the show, and humans are just a footnote in their world. They’ve been here for the longest time. If we consider the length of a desk or arms outstretched, that covers as a visual representation of the entire history of life on earth, Earth began 4.6billion years ago, life originated less than a billion years later. For over 2 billion years they ruled the planet until multi-cellular life forms emerged. Dinosaurs emerged in December and humans in the last few seconds. These little organisms that share our bodies are not just stowaways, they are in fact important parts of our lives and in many species, they bestow their hosts with incredible superpowers. - BREASTFEEDING: Breast feeding is a way for a mother to nourish a baby, but about ten percent of breast milk contains sugars called human milk oligosaccharides or HMOs; complex sugars that the babies are incapable of digesting. These sugars are there to nourish the baby's first microbes and particularly some strains of bacteria known as bifidobacterium longum infatis (B infantes for short) that have evolved to specifically digest those sugars with incredible efficiency. They also nourish the baby's gut cells they seal up the lining of the infant’s gut, and they quench inflammation, so a breastfeeding mother isn't just nourishing a baby, she's building an entire ecosystem in her infant’s gut. She is shaping a world and that world in turn shapes us. Bottle feeding might exasperate problems. Breast milk engineers the baby’s ecosystem and it provides more microbe colonists for a baby's gut. Certain countries in Africa (e.g. Ugandans) rarely suffer from diabetes, heart disease, colon cancer and other diseases more common in the developed world due to the high amount of fibre that they eat in their diet. Milk is a super food and every single mammal dissolve parts of its body to create milk to feed babies and this has evolved over millions of years. After lactose and fats, HMO’s are the third biggest part of human milk – even if babies can’t digest them. - BABIES IMMUNE SYSTEM: “To allow our first microbes to colonise newborn babies, a special class of immune cells suppresses the rest of the body's defensive assembly, which is why babies are vulnerable to infections for the first six months of life, not because their immune system is immature as is commonly believed: it's because it's deliberately stifled to give microbes a free for all window during which they can establish themselves…. Mother's milk is full of antibodies which control the microbial population of adults and babies take up these antibodies during breastfeeding.” - BOWEL CANCER: James Kinross, a GI surgeon, states that 90% of all cases of bowel cancer are entirely preventable. People born in 1950 have a much lower incident risk of bowel cancer than millennials, we also know that if you live in London you have a much higher risk of bowel cancer than in Sahara in Africa where there are tribes that have no reported cases of bowel cancer, and it probably due to the high levels of fibre that they eat as well as the environment with clean air they live in. You're 4 times more likely to get bowel cancer if you're a millennial or young person then if you were born in the 1950s or 60s. It can't be due to our genes, it's not genetic. Change doesn’t mutate and change that quickly. It must be an environmental driver. Our microbes appear to be a very important determinant. Therefore, what you eat, what you drink and how you live your life, the lifestyle choices you make are incredibly important determinant of that risk. If you live in London your risk is high but if you're a sub–Saharan African and you live in a rural environment, have buckets of fibre, you don't get bowel cancer. We don't know why this is happening, but many experts believe that the microbiome is having a role in all of this. - ANTIBIOTICS: We know antibiotics are a lifesaver and absolutely essential part of medicines, but they have been abused and they destroy your microbiome. It's not just doctors giving them out inappropriately but also in the farming community, where we know that if we give a chicken antibiotics, they will become much fatter and larger more quickly, but this is having a detrimental effect on our well-being and health. We have an internal climate change crisis going on within us. 80% of all the antibiotics used in the world are used in farming and not in medicines. This is particularly in developing countries such as India. Penicillin was first discovered by Alexander Fleming in 1928 and by 1945 everybody had access to antibiotics or penicillin. The first woman given it, literally was given half a spoonful and recovered from a disease which she would've certainly died from, and it was miraculous, but at the time that she was given it, she literally was given half the world supply. The problem with penicillin is that although it's a significant lifesaver, it's a bit like nuclear war or Armageddon, like wiping out a whole city just to kill a rat. There are many consequences of the antibiotics that we now use that are damaging our Microbiome. just as climate change and heating the atmosphere with carbon molecules is destroying our planet. The problem isn't their use, it’s their overuse of antibiotics prescribed for so many conditions that they do not need, but people are now burning up antibacterial resistance and that's a very dangerous place to be in. - 80% of the world's antibiotics are used in food production. Used in the healthcare industry. Antibiotics have been manufactured at a massive scale, and we consume huge amounts of them. We now consume about 38 billion daily doses of antibiotics globally. Many of them to given to feed those in India and China, being consumed by young people and children. Their also in the soil and water and you can't really escape them. - If you give a child lots of antibiotics early in life, their risk of obesity, risk of diabetes and their risk of asthma goes up. We know that the risk of bowel cancer and other cancers go up. But we just keep giving antibiotics. There are many different types of antibiotics and the frequency that you're prescribing can impact in different ways on our gut. Penicillin will give a temporary change in the microbiome and the mechanisms in the microbiome will bounce back, but in six weeks it will bounce back. However, if you give a broad-spectrum antibiotic, an antibiotic designed to kill more different types of bacteria, you'll see much more profound change. Sometimes the microbiome will never come back. - EMBRYOS: Every animal begins life from a single fertilized egg into a fully adult body, composed of trillions of cells. The pathway of development doesn't unfold under our own steam or under the instructions encoded within our own genome, it also occurs in partnership with our microbiome. It happens to fire conversations between us and the multitudes that we carry, so some animals don't even make that complete journey if they don't contain the right bacteria in their environment. Mice for example rely on microbial signals throughout their entire lives to shape the development of their organs which doesn’t occur in germ free mice raised in sterile conditions. The immune system sculpts our bodies they help to influence the development of our organs and that includes the immune system. the thing that's meant to keep us healthy. - ALLEGIES: They can overreact to harmless threats like dust, pollen and other allergens in the world around us, and it is thanks to microbes that we can calibrate our response that those kinds of responses striking a balance between reacting but not overreacting. In return the immune system selects for the microbes that live with us rather than indiscriminately killing them. A useful metaphor would suggest it gets to decide which species get to live with us and where they get to live. Think of the immune system more as a team of Rangers in a national park, they care for the species of the park, they decide who gets to live there, what their population sizes should be, and remove invaders. - BEHAVIOUR: Microbes influence our behaviour. There have been many studies using mice and rats. including germ-free ones. The microbes in our guts can influence the way we behave, think and everything from our resilience to stress to our susceptibility to anxiety. Aspects of personality and mood have this microbial influence though how it influences human behaviour is still unclear, but it’s entirely plausible that the microbiome shapes the way we think. There are many connections between the gut and the brain, including a so-called gut brain axis, a two-way line of communication where there are nerves that run from the gut to the brain. The immune system can send signals between the two and bacteria in our gut produced chemicals such as dopamine and serotonin, chemicals that we normally think of as responsible for signalling in the brain. - FIBRE: lack of fibre also reshaped their gut microbiome. Fibre is so complex that it creates openings for a wide range of microbes with the right digestive enzymes. The recommended amount of fibre to have each day is around 30 grammes and yet most of us are having nowhere near this amount. - AUTISM: in 2001, neuroscientist Paul Patterson injected pregnant mice with a substance that mimics a viral infection and triggers an immune response. The mice gave birth to healthy pups but as the babies grew into adults, Patterson started noticing interesting quirks in their behaviour. Mice became naturally reluctant to enter open spaces, became startled by loud noises, groom themselves over and over or repeatedly tried to bury a marble. They were less communicative than their peers and they shied away from social contact. Anxiety, repetitive movements, social problems were noted in these mice. There were similarities to the two human conditions of autism and schizophrenia. He wondered if a mother's immune response might somehow affect the development of her baby's brain. in twins, where one has autism and the other doesn't, if their microbiome is passed on to germ free mice, the one that is given the microbiome from someone with autism will often begin to show similar features as mentioned above. However, if they are then given the microbiome from a twin child that doesn't have autism, these symptoms can disappear but only up to the point where the mice are weaned. We have to be careful with these results but it does show that the microbes are at least partially responsible for these behaviours. - DATING AND RELATIONSHIPS: If you change fly’s diet, you change their sex life. In one experiment, over 25 generations of flies where one group were given starch foods to eat and the other one sweet food and within 25 generations the flies that had only eaten starch-based diet only mated with other flies of starch or those who ate sugar-based foods would only mate with the sugar flies. This experiment shows how genes and the diet can influence who we attract to even at such a profound level. Quite a lot of our sexual behaviours are also very heavily influenced by the microbiome. Rats will avoid mating with animals if they contain parasites because they can smell some of the molecules in the rat’s urine. - SANITATION: Another important point is sanitation which again has saved many lives but nowadays we have over sanitised the world that we live in so that children do not have the potential to develop a healthier microbiome, over sanitisation is harming all the good bacteria in the same way that we are doing when we over-prescribe medication. - The average human consumes and swallows something like million microbes with every with every 30g that it eats, and you share 80 million bacteria to another person when we kiss. Many animals can detect through smell if another animal is carrying pathogens and may even play a role in dating. - FAECES, FAECAL TRANSPANTS AND C-DIFF: Many animals get their microbes by eating faeces from other animals. These include cows, elephants, pandas, gorillas, rats, rabbits, dogs, iguanas, burying beetle’s, cockroaches and flies regularly each eat each other’s faces. Faecal transplants are currently being looked at and we know they can treat clostridium difficile (known as C-diff) when all other treatments have been tried. People have gone from death door to walking out of hospital cured. It’s caused by overuse of antibiotics. However, treatments in other conditions, the jury is still out but they are cheap, don’t require surgery and clinical trials, are looking into these as a form of treatment in other conditions. However, it's important that faecal transplants are monitored and it's important that we don't pass on infections although many people are doing these at home in such treatments as autism. There are 400 randomised controlled trials happening across the world trying to understand the mechanism. Giving people FT is also quite safe once people get over the yuck factor. In C-diff infections 90% of patients get completely better the compared to those taking more antibiotics. - PROBIOTICS: The book looks at probiotics and in many cases they do not have appear to have much in the way of benefits and these claims are now removed from claiming they are like a medicine, which would go through extreme trials and when they have been asked to do research into their effectiveness, the results have not been strong, although there are a few conditions such as NEC which they can be a benefit. - MICROBES ARE GOOD: We need to stop criticising and waging war against germs on microbes and realise that they are our friend, just as a gardener might plant and feed a garden. We need to make sure its nourished, fed, watered, good soil – put the same seeds in a neglected garden and they don’t bloom in the same way (or not at all). Our world is built on microbes they support us more than harm us.

uno de los libros más interesantes y entretenidos que he leído en mucho tiempo! El autor describe con habilidad y entusiasmo el mundo de los microbios: la gran variedad que hay, la importancia que tienen (como simbiontes o parásitos) por seres más grandes (humanos incluidos) y como la perspectiva científica se ha cambiado en los ultimos años de combatir los microbios a cualquier coste a aprovecharnos de sus capacidades. En mi opinión este libro contiene mucha información sobre la naturaleza y la evolución, la historia de la microbiología y la importancia de pensar sobre ecosistemas y no especies en solitario. El autor presenta un material muy rica en una manera comendable: siempre ligero de seguir (y incluso cautivador), pero sin simplificar demasiado y con mucha referencias a la literatura científica. Muy recomendable, ya le he regalado a tres personas.

I Contain Multitudes has been included on more than a dozen prominent “notable books” or “best of the year” lists, so I can only add my voice to encourage lovers of science as strongly as I can to read this book. First, it’s written the way I wish all popular science books were written: with terrific enthusiasm, unimpeachable diligence and scholarship, impeccable balance, and humour. Second, it’s collection of scientific findings is mind-blowing—you’ll learn not only that bacteria, viruses, and archaea colonize every square centimeter of our planet (and ourselves) in unimaginable numbers, but also that bacteria are brilliantly effective in producing antibacterial agents. You’ll discover wasps that spread an antibiotic paste over the eggs they lay; how mammalian mothers (including humans) provide lifetime protection to their babies via natural births and breast milk; how much we need good bacteria to help our bodies function normally, and why; and how pests like wasps and mosquitoes can be used as disease-fighters thanks to their microbiome (the collection of microbes living on and within them). To me, two of the most important takeaways of I Contain Multitudes are that 1) microbes don’t automatically mean disease—there are many more necessary or neutral microbes than there are pathogens that do us harm; and 2) when we wipe out existing colonies of (mostly harmless) microbes with antibiotics and antimicrobial chemicals, we’re opening up niches for the nearest opportunistic microbes to take their place, very likely harmful ones (in hospitals, that’s almost a certainty). So, over-sterilizing ourselves and our environments is a bad strategy. If you’re easily grossed-out, there is a significant “ick” factor in much of what Yong relates, but it’s information very much worth knowing. And I think it’s safe to say that you’ll never look at the world and the people around you in the same way again!

Escrito de forma divertida, abre nossos olhos para as redes complexas em que estamos, das inúmeras relações entre os microorganismos e nós, os seres maiores. O que está por aí, o que mora em nós, por fora e por dentro e aquilo que é tão íntimo nosso, que é, de certa forma, nós. Transforma o olhar e nos faz repensar sobre limites dos indivíduos.

Un libro che ho scoperto grazie a Bill Gates. Un'avventura affascinante per scoprire cosa avviene realmente dentro e fuori di noi, per capire perchè la medicina usa sempre di più le scoperte sui microoragnismi che vivono in simbiosi con il nostro corpo e tutti i suoi organi a partire dalla flora batterica e perchè adesso utilizzeremo sempre meno medicine e più micro organismi per guarire da un cancro alla depressione e anche autismo. Il libro è interamente scentifico ma scritto in modo da coinvolgere il lettore in una scoperta che rimarraà memorabile e lo farà agire in un modo tutto orientato al futuro: che è meraviglioso.